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Target intelligence / Profile preview
WRB-SH3BGR readthrough transcript (WRB-SH3BGR)
- Target
- WRB-SH3BGR
- Molecular classification
- Other (Readthrough/fusion gene)
01
Overview
WRB-SH3BGR readthrough is a naturally occurring chimeric transcript resulting from the readthrough transcription between WRB (encoding a mitochondrial or ER membrane protein) and SH3BGR (encoding an SH3 domain-binding glutamate-rich protein) on chromosome 21. This readthrough event generates a transcript that may encode a fusion protein sharing components of the parental proteins. There is limited information available regarding the biological function, therapeutic targeting, or disease associations of this fusion transcript, although it is annotated in genomic databases.
- Other names
- GET1-SH3BGR readthroughWRB-SH3BGRWRB-SH3BGR readthroughGET1-SH3BGR
02
Disease associations
Autism spectrum disorder (only a database association, not a validated mechanism)Other (Parental genes have literature about Down’s syndrome and heart development, but these are not directly attributed to the readthrough product)
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