WW domain-binding protein 2 (WBP2)

WW domain-binding protein 2 is a transcriptional coactivator that binds to WW domain-containing proteins through its C-terminal PY motifs, particularly interacting with molecules like YAP, TAZ, estrogen, and progesterone receptors. It has a crucial role in oncogenic signaling, especially in breast cancer, by promoting the transcriptional activity of hormone receptors and Hippo pathway effectors. It is also essential for hearing, as mutations or loss of WBP2 result in progressive sensorineural hearing loss. WBP2's dual involvement in cancer progression and normal sensory signaling highlights its importance as a potential therapeutic target and biomarker for oncology and audiology applications[1][3][7][9].

Other names

WBP-2GRAMD6DFNB107WW domain binding protein 2WBP2WW domain-binding protein 2

Acts as a transcriptional coactivator enhancing the transactivation of estrogen and progesterone receptors by interacting via PY motifs with WW domain-containing proteins such as YAP and TAZ. Dysregulation can drive oncogenic signaling in breast and other cancers[1][3][7].