WW domain-containing E3 ubiquitin protein ligase 1 (WWP1)

WW domain-containing E3 ubiquitin protein ligase 1 (WWP1) is a HECT-type E3 ubiquitin ligase crucial for protein ubiquitination and degradation, playing roles in cell proliferation, apoptosis, growth, differentiation, and signal transduction. It is implicated in various diseases, including cancer where it can act as both an oncogene and tumor suppressor, cardiac diseases, neurodevelopmental disorders, infectious diseases, and age-associated osteogenic disorders. While no approved drugs currently target WWP1, preclinical inhibitors could modulate its E3 ligase activity to block ubiquitination of key substrates like PTEN, p53, and ΔNp63α, potentially stabilizing tumor suppressors and influencing cell fate. WWP1 expression levels and HECT domain mutations are potential biomarkers for cancer prognosis. Safety concerns regarding its targeting are not fully elaborated in the provided information.

Other names

NEDD4-like E3 ubiquitin-protein ligase WWP1Atrophin-1-interacting protein 5HECT-type E3 ubiquitin transferase WWP1TGIF-interacting ubiquitin ligase 1WW domain-containing protein 1Tiul1AIP5DKFZP434D2111hSDRP1

Inhibitors would prevent E3 ligase activity, blocking ubiquitination of key substrate proteins (e.g., PTEN, p53, ΔNp63α) Potential stabilization of tumor suppressors Modulation of substrate degradation affecting cell fate decisions