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Target intelligence / Profile preview
WW domain-containing oxidoreductase (WWOX)
- Target
- WWOX
- Molecular classification
- Oxidoreductase, Short-chain dehydrogenase/reductase (SDR), Tumor Suppressor, Adaptor Protein
01
Overview
WW domain-containing oxidoreductase (WWOX) is a tumor suppressor protein that plays a critical role in apoptosis, development, and cellular stress responses. It contains two N-terminal WW domains and a C-terminal short-chain dehydrogenase/reductase (SDR) domain. WWOX interacts with numerous proteins via its WW domains, influencing various cellular pathways. Loss of WWOX expression is frequently observed in many cancers, suggesting its importance in maintaining genomic stability and preventing tumor development.
- Other names
- Fragile site FRA16D oxidoreductaseFORWWOX protein
02
Mechanism of action
WWOX acts as a tumor suppressor by inducing apoptosis and inhibiting tumor growth. It functions as an adaptor protein via its WW domains, interacting with various signaling proteins containing PPxY motifs. The SDR domain is involved in redox reactions, particularly with steroid substrates.
03
Biological functions
Tumor suppressionApoptosis inductionBone developmentNeural developmentRedox reactionsSignal transduction
04
Disease associations
CancerNeurodegenerative diseaseNeuronal injury
05
Safety considerations
Loss or reduction of WWOX function/expression is associated with poor prognosis in multiple tumor types.Subcellular localization discrepancies might complicate targeted therapies.
06
Biomarkers
WWOX expression levels as a prognostic marker in cancer
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