X antigen family member 1A (XAGE1A)

X antigen family member 1A (XAGE1A) is a member of the GAGE family of cancer-testis (CT) antigens, characterized by expression in various tumors (such as Ewing’s sarcoma, rhabdomyosarcoma, and ovarian carcinoma) and normal testis, but generally not in other normal tissues[1][2][3][5][6]. The protein contains a nuclear localization signal, and alternative splicing produces multiple isoforms. XAGE1A and related CT antigens are involved in normal germ cell biology (spermatogenesis) and may contribute to tumor development and metastatic progression, notably through mechanisms such as apoptosis avoidance and potentially promoting epithelial-to-mesenchymal transition (EMT)[2][4]. High XAGE1A expression serves as a specific biomarker for several cancers—especially ovarian cancer, where it can differentiate malignant from benign lesions and is linked to poor prognosis and advanced stage[2][6]. XAGE1A is being investigated as a candidate for cancer diagnosis and immunotherapy[2][4][6]. No direct information is available for approved drug interactions or specific molecular inhibitors.

Other names

XAGE-1CT12.1Cancer/testis antigen 12.1G antigen family D member 2GAGED2CTP9CT12.1AXAGE1XAGE1BXAGE1CXAGE1Dprotein XAGE-1