X-ray repair cross-complementing protein 3 (XRCC3)

X-ray repair cross-complementing protein 3 (XRCC3) is a member of the RecA/Rad51-related protein family that is essential for the homologous recombination repair (HRR) pathway of double-stranded DNA, promoting chromosomal stability by repairing DNA damage such as chromosomal fragmentation, translocations, and deletions. XRCC3 acts as a partner within protein complexes (notably, the RAD51 paralog complexes) involved in late stages of homologous recombination, including processing Holliday junctions and maintaining genome integrity. Genetic variations in XRCC3 are associated with altered cancer susceptibility and radiosensitivity. Key distinctions: - XRCC3 is distinct from XRCC1, another DNA repair protein, and is primarily involved in homologous recombination, not single-strand break repair. - There are currently no drugs that directly target XRCC3, but its status in HR pathways makes it relevant to synthetic lethality strategies in cancer therapy.

Other names

XRCC3X-ray repair cross complementing 3DNA repair protein XRCC3

Not typically a direct drug target, but drugs targeting homologous recombination and DNA repair pathways may indirectly affect XRCC3 function (e.g., synthetic lethality with PARP inhibitors in HR-deficient cancers)