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Target intelligence / Profile preview
Xeroderma Pigmentosum Group B Protein (XPB)
- Target
- XPB
- Molecular classification
- DNA Helicase, Transcription Factor, ATP-dependent DNA translocase
01
Overview
XPB (xeroderma pigmentosum type B), encoded by the ERCC3 gene, is an essential ATP-dependent DNA helicase and a core subunit of the general transcription factor IIH (TFIIH) complex. It plays critical roles in both basal transcription and nucleotide excision repair (NER). XPB’s double-stranded DNA translocase activity helps open the promoter region for transcription initiation and assists in unwinding damaged DNA regions during NER. Mutations in XPB cause Xeroderma pigmentosum group B and combined xeroderma pigmentosum/Cockayne syndrome. Triptolide is a natural product that targets XPB, inhibiting its ATPase activity and suppressing global gene expression, being explored for anti-cancer therapies.
- Other names
- ERCC3
02
Mechanism of action
Triptolide covalently binds to XPB/ERCC3 within TFIIH, inhibiting its DNA-dependent ATPase activity and blocking overall NER capacity, suppressing global gene expression.
03
Biological functions
Basal Transcription InitiationNucleotide Excision RepairTranscription-Coupled RepairApoptosis
04
Disease associations
Xeroderma pigmentosum group B (XP-B)Cockayne syndromeCancer
05
Safety considerations
Triptolide has significant toxicity limiting its clinical use.
06
Interacting drugs
Triptolide
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