Xeroderma pigmentosum group C mRNA (XPC mRNA) (XPC mRNA)

Xeroderma pigmentosum group C mRNA (XPC mRNA) is the transcript encoding the XPC protein, which serves as the primary initiator of the Global Genome Nucleotide Excision Repair (GG-NER) pathway (UniProt: Q01831). The XPC protein complex is responsible for the initial recognition of bulky DNA lesions, such as those induced by ultraviolet (UV) radiation, and facilitates the recruitment of subsequent repair factors (NCBI Gene: 7508). Mutations in the XPC gene lead to Xeroderma Pigmentosum group C, a rare genetic disorder characterized by extreme photosensitivity and a vastly increased risk of developing skin cancers (PubMed: 21854231). As a therapeutic target, XPC mRNA is primarily being investigated for mRNA replacement therapy, where synthetic mRNA is delivered to the skin to restore functional XPC protein levels and DNA repair capacity (PubMed: 33055244). This approach aims to provide a localized treatment to prevent the onset of malignancies in affected patients. Current challenges include ensuring stable delivery to the epidermis and managing potential inflammatory responses to the synthetic nucleic acids.

Other names

XP3XPCCp125Xeroderma pigmentosum group C-complementing protein mRNA

mRNA replacement therapy to restore functional XPC protein and Global Genome Nucleotide Excision Repair (GG-NER) activity