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Target intelligence / Profile preview
XIAP antisense RNA 1 (XIAP-AS1)
- Target
- XIAP-AS1
- Molecular classification
- Long non-coding RNA (lncRNA)
01
Overview
XIAP antisense RNA 1 (XIAP-AS1) is a long non-coding RNA that regulates the expression of the X-linked inhibitor of apoptosis protein (XIAP) gene. XIAP-AS1 increases XIAP transcription by interacting with the transcription factor Sp1, which results in reduced apoptosis and promotes tumor progression. XIAP-AS1 has been shown to play an oncogenic role, especially in gastric cancer, by facilitating STAT3 activation and epithelial-mesenchymal transition (EMT) marker expression. Elevated XIAP-AS1 levels have been associated with enhanced tumor cell survival and poorer clinical outcomes. Although XIAP protein is a validated therapeutic target, targeting XIAP-AS1 itself for therapy is still under investigation and has not led to clinically established drugs. XIAP-AS1 may serve as a biomarker for cancer prognosis and response to therapy but is not established as a direct drug target.
- Other names
- XIAP-AS1XIAP antisense RNA 1
02
Mechanism of action
Not applicable
03
Biological functions
Regulation of gene transcription (specifically increases transcription of XIAP by interacting with transcription factor Sp1)Modulation of apoptosis (via XIAP)Regulation of oncogenic pathways, such as STAT3 phosphorylation and EMT marker expression
04
Disease associations
Cancer (implicated in gastric cancer and other solid tumors via its regulation of XIAP and tumor cell survival)
05
Safety considerations
None specific to XIAP-AS1 as a therapeutic targetTherapeutic targeting of lncRNAs remains experimentally challenging, with risks of off-target effects and unclear pharmacology
06
Biomarkers
Expression of XIAP-AS1 may serve as a biomarker for poor prognosis or therapeutic response in certain cancers (especially gastric cancer)XIAP mRNA and protein levels (indirect biomarker)
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