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Target intelligence / Profile preview
Y-box Binding Protein 1 (YB-1)
- Target
- YB-1
- Molecular classification
- Transcription factor, RNA-binding protein, DNA-binding protein
01
Overview
Y-box Binding Protein 1 (YB-1) is a highly conserved, multifunctional DNA and RNA-binding protein involved in various aspects of nucleic acid metabolism, including transcription, translation, DNA repair, and mRNA splicing. It plays a significant role in cancer biology, particularly in cell proliferation, survival, metastasis, and drug resistance, making it a promising therapeutic target and biomarker. Regulation occurs at multiple levels, including expression, localization, and post-translational modifications like phosphorylation and PARylation.
- Other names
- YBX1
02
Mechanism of action
Inhibition of YB-1 expression or activity
03
Biological functions
Transcription regulationDNA replicationDNA repairChromatin remodelingmRNA splicingmRNA packaging into ribonucleoprotein particlesRegulation of mRNA stabilityRegulation of mRNA translationCell proliferationCell differentiationStress response
04
Disease associations
CancerDrug resistance
05
Safety considerations
Potential harm to healthy cellsOff-target effects
06
Biomarkers
YB-1 overexpressionNuclear localization of YB-1
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