Y-box binding protein 1 mRNA (YBX1 mRNA)

Y-box binding protein 1 (YBX1) mRNA encodes a highly conserved, multifunctional protein that belongs to the cold-shock domain family (UniProt P67809). This mRNA is a critical regulator of gene expression, influencing transcription in the nucleus and translation and stability of various mRNAs in the cytoplasm (NCBI Gene ID: 4904). In many human cancers, including breast, lung, and prostate cancer, YBX1 mRNA is significantly overexpressed and serves as a potent oncogene that promotes cell proliferation, epithelial-mesenchymal transition (EMT), and resistance to chemotherapy (PMID: 24631444). Targeting the YBX1 mRNA directly using antisense oligonucleotides (ASOs) or small interfering RNAs (siRNAs) has demonstrated efficacy in preclinical models by reducing YBX1 protein levels and sensitizing tumor cells to apoptosis (PMID: 11507054). Beyond oncology, YBX1 mRNA is implicated in the regulation of inflammatory cytokines and fibrotic pathways, making it a potential target for treating chronic inflammatory and fibrotic diseases (PMID: 30038245). Therapeutic strategies focusing on the mRNA aim to silence YBX1 expression at the pre-translational level, offering a way to bypass the "undruggable" nature of the YBX1 protein's disordered regions. However, therapeutic development faces challenges such as the need for efficient systemic delivery systems and the potential for off-target effects due to the mRNA's structural complexity.

Other names

YB-1 mRNANSEP1 mRNAY-box-binding protein 1 messenger RNANuclease-sensitive element-binding protein 1 mRNADNA-binding protein B mRNAMDR-NF1 mRNA

Antisense oligonucleotides or small interfering RNAs bind to the YBX1 mRNA through complementary base pairing, leading to mRNA degradation via RNase H or the RNA-induced silencing complex (RISC), thereby preventing the translation of the YBX1 protein (PMID: 11507054, PMID: 30038245).