Yae1 domain-containing protein 1 (YAE1)

Yae1 domain-containing protein 1 (YAE1, also known as Protein YAE1 homolog, C7orf36, YAE1D1, etc.) is an evolutionarily conserved protein that acts as a target-specific adaptor in the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery[1][3]. YAE1, together with its partner LTO1, is responsible for facilitating the insertion of Fe-S clusters specifically onto the essential ribosome-associated ABC-type ATPase ABCE1 (called Rli1 in yeast), which is crucial for ribosome biogenesis, recycling, and translation[1][3]. YAE1 does not act as a general chaperone or maturation factor for all cytosolic Fe-S proteins but is specific for ABCE1 maturation[1][3]. Both YAE1 and LTO1 are essential proteins, and their loss impairs translation similarly to ABCE1 loss[3]. Their function also appears to include protection of ABCE1's Fe-S clusters from oxidative stress[1][3]. No drugs are currently known to target YAE1, and its role is not associated with direct involvement in classical human disease mechanisms, but it is vital for cellular viability and protein synthesis[1][3].

Other names

Protein YAE1 homologC7orf36YAE1D1GK003CIAB2ABCE1 maturation factorYae1 domain containing 1