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Target intelligence / Profile preview
YAP–TEAD Protein Interaction (YAP-TEAD)
- Target
- YAP-TEAD
- Molecular classification
- Protein-Protein Interaction, Transcription factor complex
01
Overview
The YAP–TEAD protein interaction is a critical interface between Yes-associated protein (YAP) and TEA domain family transcription factors (TEAD1-4). This interaction regulates gene expression programs controlling cell proliferation, survival, and organ size. Disrupting this interaction is a therapeutic strategy for cancer.
- Other names
- Yes-associated protein – Transcriptional enhancer factor domain familyYAP/TAZ-TEAD interaction
02
Mechanism of action
Disruption of YAP-TEAD interaction, inhibiting downstream gene expression
03
Biological functions
Cell proliferationCell survivalGene expression regulationTranscriptional coactivation
04
Disease associations
CancerOncogenesisMetastasis
05
Safety considerations
Potential for off-target effects due to widespread role in development and homeostasis
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