YAP1 divergent transcript (YAP1-DT)

YAP1 divergent transcript (YAP1-DT, AC107464.2) is annotated as a long non-coding RNA (lncRNA) transcribed from the genomic region divergent to the protein-coding gene YAP1 (Yes1 associated transcriptional regulator). YAP1 itself is a major effector in the Hippo signaling pathway and widely studied for roles in development, cancer, and cell proliferation[3]. However, as of current public data and expert resources, YAP1-DT has no reported protein-coding capacity, no established molecular function, and is not recognized as a standalone therapeutic target or validated disease gene. YAP1-DT is sometimes included in transcriptomic studies as a locus of interest related to YAP1 regulation, but there is no evidence that it functions as a receptor, enzyme, transporter, or similar druggable entity. Most functional studies on "YAP1" or the "Hippo pathway" refer to the protein-coding YAP1 gene, not the YAP1 divergent transcript. The lncRNA's biological significance (if any) is currently unclear and not associated with pharmacological interventions, disease mechanisms, or biomarker utility. If you intended to ask about the protein-coding gene "YAP1" (Yes1 associated transcriptional regulator), that is a well-characterized transcriptional co-activator and a component of the Hippo signaling pathway involved in cell proliferation and cancer[3][4][1][2], but it is distinct from the non-coding YAP1-DT. Key clarification: - If your query is about **YAP1 the protein**, that is a valid and important therapeutic target. - If your query is specifically about **YAP1-DT/AC107464.2**, it is not a drug target or validated disease gene; it is a non-coding RNA with unknown function. No evidence of interacting drugs, mechanism of action, biomarker or safety data exists for YAP1-DT as of this review.

Other names

YAP1 divergent transcriptAC107464.2