Target intelligence / Profile preview

Yeast Cytosine Deaminase (yCD)

Target: yCD
Molecular classification: Enzyme, Metalloenzyme

Overview

Yeast cytosine deaminase (yCD) is an enzyme that catalyzes the hydrolytic deamination of cytosine to uracil. It is involved in pyrimidine salvage. Its ability to convert the non-toxic prodrug 5-fluorocytosine (5FC) into the chemotherapeutic agent 5-fluorouracil (5FU) makes it useful in gene-directed enzyme prodrug therapy (GDEPT) for cancer treatment. Mammalian cells lack this enzyme, allowing for selective killing of tumor cells expressing yCD.

Other names: Cytosine deaminaseCytosine aminohydrolaseFCY1

Mechanism of action

Converts 5-fluorocytosine (5FC) into 5-fluorouracil (5FU)

Biological functions

Pyrimidine salvageHydrolytic deamination of cytosine to uracil

Disease associations

Cancer

Safety considerations

Potential for off-target effects if expression of yCD is not strictly limited to tumor cells.Immunogenicity of the enzyme.

Interacting drugs

5-Fluorocytosine (5FC)

1 more in the full profile.

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