Target intelligence / Profile preview

YEATS Domain-Containing Protein 1

Molecular classification: Transcription factor, Chromatin regulator, Epigenetic reader, YEATS domain family

Overview

YEATS Domain-Containing Protein 1 is a member of the YEATS domain family, evolutionarily conserved proteins involved in chromatin regulation and gene expression. The YEATS domain recognizes acetylated lysines on histones, acting as an epigenetic "reader." It participates in chromatin-remodeling complexes and regulates gene expression by modulating chromatin accessibility. It is implicated in oncogenesis, particularly in acute myeloid leukemia (AML), where it binds acetylated histones at oncogenic loci, driving aberrant gene expression.

Biological functions

Transcription regulationChromatin remodelingHistone bindingEpigenetic signaling

Disease associations

Cancer

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