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Target intelligence / Profile preview
Yellow Fever Virus Replication Cycle (YFV Replication)
- Target
- YFV Replication
- Molecular classification
- Viral Replication Process
01
Overview
The yellow fever virus (YFV) replication cycle is a complex process involving attachment and entry, translation of a polyprotein, processing of the polyprotein into functional viral proteins, replication of the viral RNA genome, assembly of new virions, and release of the virus from the infected cell. This cycle occurs entirely within the cytoplasm of infected cells, primarily hepatocytes, and is crucial for viral propagation and the pathogenesis of yellow fever.
- Other names
- Yellow Fever Virus Life CycleYFV Replication
02
Mechanism of action
Ribavirin inhibits flavivirus genome replication (general). Triazole derivatives inhibit YFV replication through unknown mechanisms.
03
Biological functions
Viral genome replicationViral protein synthesisVirion assemblyViral entryViral egress
04
Disease associations
Yellow fever pathogenesisViral infection
05
Safety considerations
Lack of specific and effective antiviral treatments for YFV.Potential for resistance mutations to antiviral therapies.
06
Interacting drugs
Ribavirin
1 more in the full profile.
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