Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Yersinia pestis (Y. pestis)
- Target
- Y. pestis
- Molecular classification
- Bacterium, Gram-negative bacterium, Coccobacillus, Pathogen
01
Overview
Yersinia pestis is a Gram-negative bacterium and the causative agent of plague. It possesses several virulence factors, including a type III secretion system (T3SS), Yops proteins, LcrV antigen, and yersiniabactin, which contribute to its pathogenicity by suppressing the host's immune response and facilitating iron acquisition. Transmission occurs primarily through flea bites or contact with infected animals or tissues. The bacterium can cause bubonic, septicemic, and pneumonic plague.
- Other names
- Pasteurella pestis
02
Mechanism of action
Antibiotics target bacterial cell wall synthesis, protein synthesis, or DNA replication to inhibit bacterial growth or kill the bacteria.
03
Biological functions
InfectionColonizationImmune evasionIron acquisitionType III secretion system (T3SS)AdhesionInvasion
04
Disease associations
Plague (bubonic, septicemic, pneumonic)
05
Safety considerations
Antibiotic resistanceTreatment failureSeptic shockHigh mortality if untreated
06
Interacting drugs
Antibiotics (e.g., tetracyclines, streptomycin, chloramphenicol, fluoroquinolones)
Beyond the preview
Go deeper on Yersinia pestis (Y. pestis).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Yersinia pestis (Y. pestis).