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Target intelligence / Profile preview
Yersinia pestis F1 Capsular Antigen (F1 antigen)
- Target
- F1 antigen
- Molecular classification
- Protein, Capsular Antigen, Virulence Factor
01
Overview
The F1 capsular antigen is a major surface component of *Yersinia pestis*, the bacterium responsible for plague. It forms a capsule-like structure around the bacterium, which is highly expressed at mammalian body temperature. The capsule is composed of polymeric protein fibrils made up of repeating units of the Caf1 protein subunit. It inhibits phagocytosis by host macrophages, contributing to immune evasion during infection and is a target for vaccine development.
- Other names
- Fraction 1 antigenF1 capsular antigenCaf1YPMT_184Y1100YP_pMT082
02
Mechanism of action
N/A
03
Biological functions
Immune evasionAntiphagocytosisVirulenceCapsule formation
04
Disease associations
InfectionPlague
05
Biomarkers
Anti-F1 antibodies (diagnostic marker)
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