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Target intelligence / Profile preview
YES-associated protein–transcriptional enhancer factor domain complex
- Molecular classification
- Transcription factor complex
01
Overview
The YES-associated protein–transcriptional enhancer factor domain complex (YAP–TEAD) is a key transcriptional regulator involved in cell proliferation, growth, and survival. YAP, a transcriptional co-activator, interacts with TEAD transcription factors to promote the expression of genes involved in these processes. The activity of YAP is regulated by the Hippo signaling pathway, with phosphorylation leading to cytoplasmic retention and degradation, while dephosphorylation allows nuclear translocation and TEAD binding. Dysregulation of the YAP-TEAD complex is implicated in various cancers, making it a potential therapeutic target.
- Other names
- YAP-TEAD ComplexYAP1-TEAD Complex
02
Mechanism of action
Inhibition of YAP-TEAD interaction
03
Biological functions
Cell proliferationInhibition of apoptosisTissue growthRegenerationTranscriptional coactivation
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effects due to the broad role of YAP/TEAD in tissue homeostasisDevelopment of resistance through bypass mechanisms
06
Biomarkers
YAP expression levelsTEAD expression levelsExpression of YAP target genes (e.g., CTGF, Cyr61)
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