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Target intelligence / Profile preview
Yes-associated protein 1 (YAP1)
- Target
- YAP1
- Molecular classification
- Transcriptional coactivator
01
Overview
Yes-associated protein 1 (YAP1) is a transcriptional coactivator and a key downstream effector of the Hippo signaling pathway. It plays a central role in regulating organ size, tissue regeneration, cell proliferation, apoptosis suppression, and tumorigenesis. YAP1 promotes the expression of genes involved in cell proliferation and suppresses apoptotic genes. In its dephosphorylated state, it translocates to the nucleus where it binds TEAD family transcription factors to drive target gene expression. When phosphorylated by upstream Hippo pathway kinases such as LATS/MST, it is sequestered in the cytoplasm or targeted for degradation.
- Other names
- YAPYAP65
02
Mechanism of action
Transcriptional coactivation via binding to TEAD family transcription factors
03
Biological functions
Cell proliferationApoptosis suppressionOrgan size controlTissue regenerationStem cell self-renewalCell fate determination
04
Disease associations
Cancer
05
Safety considerations
Oncogenic potential due to amplification/overexpression in various cancersTherapy resistance
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