Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Yes Proto-oncogene Protein Tyrosine Kinase (YES)
- Target
- YES
- Molecular classification
- Enzyme, Protein Kinase, Tyrosine Kinase, Non-receptor Tyrosine Kinase, Src family kinase, Proto-oncogene
01
Overview
YES1 is a non-receptor tyrosine kinase belonging to the Src family. It is involved in various cellular processes including cell growth, survival, apoptosis, cell adhesion, and cytoskeleton remodeling. Aberrant activity or overexpression of YES1 can contribute to oncogenic transformation, making it a potential target for cancer therapy. YES1 interacts with several proteins and participates in signaling cascades related to growth factor receptors and immune responses.
- Other names
- YES1Yamaguchi sarcoma viral oncogene homolog 1p61Yesc-Yes
02
Mechanism of action
Tyrosine kinase inhibition (potential)
03
Biological functions
Regulation of cell growthCell survivalApoptosisCell-cell adhesionCytoskeleton remodelingCell differentiationSignal transductionT-cell migrationG1 phase progression
04
Disease associations
CancerOncogenesis
05
Safety considerations
Potential for off-target effects due to kinase family similaritiesDevelopment of resistance
Beyond the preview
Go deeper on Yes Proto-oncogene Protein Tyrosine Kinase (YES).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Yes Proto-oncogene Protein Tyrosine Kinase (YES).