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Target intelligence / Profile preview
YES Proto-oncogene Tyrosine-Protein Kinase (YES1)
- Target
- YES1
- Molecular classification
- Enzyme, Kinase, Tyrosine Kinase, Non-receptor tyrosine kinase, Src family kinase
01
Overview
Tyrosine-protein kinase Yes (YES1) is a non-receptor tyrosine kinase belonging to the Src family. It plays a critical role in various cellular processes including cell growth, survival, apoptosis, cell adhesion, and cytoskeletal dynamics. It is considered an oncogenic target in several cancers, including small cell lung cancer.
- Other names
- Tyrosine-protein kinase YesProto-oncogene c-Yesp61-Yes
02
Mechanism of action
Tyrosine kinase inhibition
03
Biological functions
Regulation of cell growth and survivalApoptosisCell-cell adhesionCytoskeleton remodelingCellular differentiationSignal transductionCell migrationRegulation of transcriptionProtein phosphorylation
04
Disease associations
CancerSmall Cell Lung Cancer (SCLC)Tumorigenesis
05
Safety considerations
Potential for off-target effects due to kinase family similaritiesDevelopment of resistance mechanisms
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