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Target intelligence / Profile preview
Yes1 associated transcriptional regulator (YAP1)
- Target
- YAP1
- Molecular classification
- Transcription co-regulator
01
Overview
The Yes1 associated transcriptional regulator, YAP1, is a key nuclear effector in the Hippo signaling pathway. It functions as a transcriptional co-activator, promoting cell proliferation and inhibiting apoptosis by interacting with TEAD family transcription factors. YAP1 plays a critical role in regulating organ size, tissue growth, and homeostasis, and is implicated in multiple cancers due to its pro-tumorigenic activity.
- Other names
- YAPYAP65
02
Mechanism of action
Inhibition of YAP1 transcriptional activity, reduction of YAP1 expression
03
Biological functions
Cell proliferationApoptosis inhibitionOrgan size regulationTissue growthRegenerationHomeostasisMechanotransductionGene expression regulation
04
Disease associations
CancerHepatocellular carcinomaThoracic dystrophy syndromesAtaxia-telangiectasia syndrome-like featuresCongenital ocular coloboma/intellectual disability syndromesMultiple myeloma
05
Safety considerations
Potential for off-target effects due to broad role in cellular processesResistance mechanisms may develop with prolonged inhibitionInhibition may disrupt normal tissue homeostasis
06
Interacting drugs
Sorafenib
07
Biomarkers
YAP1 expression levels in tumor tissue
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