Yip1 domain family member 2 (YIPF2)

Yip1 domain family member 2 (YIPF2) is a multi-span transmembrane protein localized primarily in the medial to trans-Golgi apparatus and partially in the trans-Golgi network[2][3]. This protein is part of the Yip1 domain family, which has a role in vesicular trafficking within the Golgi, and between the endoplasmic reticulum (ER) and Golgi compartments[1][2][3]. YIPF2 forms stable complexes with related YIPF proteins such as YIPF1 and YIPF6, which is essential for Golgi apparatus reassembly after stress, and normal glycan synthesis[2][3]. Structurally, YIPF2 is predicted to traverse the membrane five times, with a cytosolic N-terminus and a luminal C-terminus[4]. Recent studies also demonstrate that YIPF2 can interact with several Rab GTPases (Rab5, Rab22a, Rab8), and likely regulates their recruitment and cycling at the Golgi and ER, implicating YIPF2 in membrane trafficking and protein sorting pathways[4]. Depletion of YIPF2 disrupts normal Golgi functions and hinders homologous recombination repair of DNA, thus contributing to genome instability and suggesting a broader implication in maintaining cellular homeostasis and possibly influencing disease states where intracellular trafficking or genome maintenance is compromised[1][2][3]. There are currently no known drugs directly targeting YIPF2, and it is not considered a current therapeutic target or clinical biomarker. There is also no literature describing specific safety concerns or adverse effects related to modulation or loss of YIPF2 in humans.

Other names

Protein YIPF2MGC3262FinGER2Yip5CYIPFbeta3BYIP1 family member 2