Yip1 domain family member 3 (YIPF3)

Yip1 domain family member 3 (YIPF3) is a Golgi-resident transmembrane protein involved in the maintenance of Golgi apparatus structure and acts as a selective autophagy (Golgiphagy) receptor by binding ATG8 family proteins through its cytosolic N-terminal LIR motif, which is regulated by phosphorylation. The YIPF3–YIPF4 complex is essential for targeting Golgi fragments to lysosomes for degradation during autophagy, particularly under starvation. YIPF3 is expressed in various tissues and may also have a role in hematopoiesis and cell differentiation. Mutations or dysfunction in YIPF3 are associated with certain congenital diseases, but there is no evidence it is a current therapeutic target or interacts with drugs[1][2][3][4][5].

Other names

Protein YIPF336 kDa form IIIC6orf109KLIP1DKFZp566C243dJ337H4.3FinGER3Yip5bYIPFbeta2Killer lineage protein 1Natural killer cell-specific antigen KLIP1