Yip1 domain family member 5 (YIPF5)

Yip1 domain family member 5 (YIPF5) is a five-pass transmembrane protein localized predominantly at ER exit sites, the ER-Golgi intermediate compartment, and the cis-Golgi. It plays a critical role in protein and vesicle transport from the endoplasmic reticulum (ER) to the Golgi apparatus, specifically in the anterograde pathway and possibly also in maintaining Golgi/ER structural integrity[1][3][4]. In pancreatic beta cells, YIPF5 is required for the export of proinsulin from the ER to the Golgi and is essential for proper insulin processing[3][4]. Deficiency of YIPF5 leads to ER stress, accumulation of proinsulin in the ER, upregulation of the unfolded protein response, and apoptosis via pro-apoptotic proteins such as PUMA and DP5, particularly in beta cells[1]. In humans, loss-of-function mutations cause a syndrome characterized by neonatal or early-infantile diabetes, microcephaly, and often epilepsy, indicating a crucial role in neural and beta-cell development and survival[1][4]. YIPF5 interacts with components of the COPII vesicle coat and other proteins involved in intracellular trafficking[2].\n\nNo evidence currently supports consideration of YIPF5 as a direct therapeutic target (such as a receptor, enzyme, or transporter for drugs), nor are interacting drugs or established biomarker uses reported[1][4].

Other names

Protein YIPF5FINGER5YIP1APP12723SB140UNQ3123/PRO10275SMAP-5FinGER5Yip1aYIPFalpha1AFive-pass transmembrane protein localizing in the Golgi apparatus and the endoplasmic reticulum 5Smooth muscle cell-associated protein 5YIP1 family member 5YPT-interacting protein 1 AMEDS2SMAP5golgi membrane protein SB140smooth muscle cell associated protein 5