Yip1 domain family member 6 (YIPF6)

Yip1 domain family member 6 (YIPF6) is a transmembrane protein found in the ER and Golgi apparatus, with five membrane-spanning domains and a cytoplasmic N-terminal domain. YIPF6 forms complexes with other YIPF proteins (YIPF1, YIPF2) for Golgi function and glycan synthesis, and is essential for the normal secretion of select cargo proteins, notably fibroblast growth factor 21 (FGF21), by acting as a cargo receptor that facilitates FGF21 sorting into COPII vesicles. In mouse models, YIPF6 mutations cause spontaneous intestinal inflammation and sensitivity to colitis, and in the liver, loss of YIPF6 leads to increased FGF21 secretion, protecting against diet-induced obesity and hepatic steatosis. YIPF6 therefore plays a critical role in membrane trafficking, protein secretion, and metabolic and inflammatory disease, making it a candidate therapeutic target in these contexts.

Other names

Protein YIPF6MGC21416FinGER6Yip4YIPFalpha3YIP1 family member 6

YIPF6 acts as a cargo receptor for the packaging and selective secretion of FGF21 via COPII vesicles; modulation of its function could indirectly affect FGF21 levels, an established therapeutic axis in metabolic diseases