YTH N6-methyladenosine RNA-binding protein 1 (YTHDF1)

YTH N6-methyladenosine RNA-binding protein 1 (YTHDF1) is an m6A reader protein that recognizes N6-methyladenosine (m6A) modifications on RNA, primarily promoting the translation of m6A-modified transcripts by enhancing ribosome recruitment and increasing translation efficiency[1][2][6]. It plays a critical role in regulating post-transcriptional gene expression, affecting both translation and stability of target mRNAs. YTHDF1 is particularly important in cancer progression, functioning as either a tumor promoter or suppressor depending on the specific gene targets and context[1][6]. By interacting with translation machinery and other co-factors such as eukaryotic initiation factors, YTHDF1 modulates cellular responses including cell proliferation, immune response, and possibly response to viral infection[1][2][6][8]. No small-molecule drugs targeting YTHDF1 have been approved, but its central role in mRNA metabolism and cancer makes it a candidate for therapeutic intervention.

Other names

YTH domain-containing family protein 1C20orf21DF1DACA-1FLJ20391Dermatomyositis associated with cancer putative autoantigen 1

Enhancement of translation initiation and elongation of m6A-modified transcripts Promotion of ribosome occupancy on target mRNAs Regulation of mRNA stability via binding to m6A sites