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YY1 divergent transcript (YY1-DT)
- Target
- YY1-DT
- Molecular classification
- Long noncoding RNA, Other (specifically, disease-associated lncRNA)
01
Overview
YY1 divergent transcript (YY1-DT), also known as RP11-638I2.4, is a long noncoding RNA that functions by interacting with the transcription factor YY1. A particular transcript isoform, MICT00000110172.1, can reinforce interaction with YY1 and modulate the effect of YY1 on the cell cycle in pancreatic cancer. A single nucleotide polymorphism (rs2757535) in the second exon of this transcript alters its structure and its affinity for YY1, affecting allele-specific cancer susceptibility. Current research highlights its function in cancer biology and suggests it may serve as a starting point for lncRNA-based therapeutic exploration, but it is not a therapeutic target in the classic sense[1].
- Other names
- RP11-638I2.4lncRNA-YY1-DTMICT00000110172.1
02
Mechanism of action
Not applicable; no drugs target this transcript directly.
03
Biological functions
Regulation of gene expression through modulation of transcription factor (YY1) activityPossibly involved in cell cycle regulation in cancer
04
Disease associations
Cancer (pancreatic cancer susceptibility/progression)Other (likely relevant to additional conditions where YY1 is involved, though primary evidence is for cancer)
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