YY2 transcription factor (YY2)

YY2 transcription factor is a zinc finger DNA-binding protein and paralog of YY1, containing multiple Kruppel-like zinc fingers in its C-terminal region that enable it to perform both activation and repression of gene transcription. YY2 exhibits homology and overlapping functionality with YY1 but also has non-redundant roles in gene regulation, counteracting YY1 activity in certain contexts and exerting unique effects in cell proliferation, cancer biology (as a tumor suppressor through modulation of ferroptosis and metastasis suppressors), stem cell maintenance, tissue development, differentiation, and bone physiology. YY2 regulates a distinct subset of genes, influences responses to DNA damage, and its binding to enhancer regions can modulate gene expression relevant to specific diseases such as osteoporosis and various cancers

Other names

Transcription factor YY2YY2ZNF631YY-2Yin and yang 2Zinc finger protein 631transcription factor yin yang 2transcription factor YY2yen and yang 2zinc finger protein 631