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Glycoprotein (GP)
- Target
- GP
- Molecular classification
- Glycoprotein, Viral protein, Type I fusion protein
01
Overview
The Glycoprotein of Zaire ebolavirus is an essential structural protein responsible for mediating viral entry through receptor binding and membrane fusion. Its complex structure—including heavy glycosylation—enables immune evasion but also provides key targets for neutralizing antibodies, vaccines, and therapeutics. Recombinant versions are widely used in research settings due to their central role in infection biology.
- Other names
- EBOV GPZaire ebolavirus glycoproteinEbola virus glycoproteinGP1GP2sGPssGPshed GP
02
Mechanism of action
Inhibition of receptor binding, disruption of membrane fusion
03
Biological functions
Viral entryReceptor bindingMembrane fusionImmune evasion
04
Disease associations
InfectionEbola virus diseaseViral pathogenesis
05
Safety considerations
Potential for antibody-dependent enhancement (ADE)Glycosylation hinders effective antibody bindingHigh sequence variability
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