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Target intelligence / Profile preview
Zaire ebolavirus Large Polymerase Protein
- Molecular classification
- Enzyme, RNA-dependent RNA polymerase
01
Overview
The Zaire ebolavirus L polymerase is a large, multifunctional RNA-dependent RNA polymerase essential for the replication and transcription of the Ebola virus genome. It catalyzes transcription of viral mRNAs, capping and polyadenylation of mRNAs, and replication of viral genomic RNA. It is a critical component of the viral ribonucleoprotein complex and serves as a promising target for antiviral drug development due to its central role in the virus life cycle.
- Other names
- Zaire ebolavirus L polymeraseRNA-directed RNA polymerase (L protein)Ebola virus L protein
02
Mechanism of action
Suramin binds at the highly conserved NTP entry channel on EBOV-L-VP35 complex to block substrate access to active site
03
Biological functions
Viral genome replicationViral transcriptionmRNA cappingmRNA polyadenylation
04
Disease associations
Infection
05
Safety considerations
Potential for off-target effects due to sequence homology with host polymerases.Development of drug resistance.
06
Interacting drugs
Suramin
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