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Target intelligence / Profile preview
Zaire ebolavirus Matrix Protein VP40 (VP40)
- Target
- VP40
- Molecular classification
- Matrix protein, Viral structural protein
01
Overview
VP40 is the major matrix protein of Zaire ebolavirus, essential for virion assembly, budding, and morphogenesis at the host cell plasma membrane. It functions as a key structural component and regulates viral transcription, packaging, morphogenesis, and suppression of host RNA silencing. Its central role in the viral life cycle makes it a prime target for antiviral drug development and a valuable tool for VLP-based vaccine development and research.
- Other names
- EBOV VP40Ebola virus VP40Matrix protein VP40
02
Mechanism of action
N/A
03
Biological functions
Virion assemblyVirion buddingViral matrix formationRegulation of viral transcriptionPackagingMorphogenesisSuppression of host RNA silencing
04
Disease associations
Ebola virus disease (EVD)Viral infection
05
Safety considerations
High pathogenicity of Ebola virusPotential for resistance development against VP40-targeting therapeutics
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