Target intelligence / Profile preview

ZBED3 antisense RNA 1 (ZBED3-AS1)

Target: ZBED3-AS1
Molecular classification: Long non-coding RNA, Other

Overview

ZBED3 antisense RNA 1 (ZBED3-AS1) is a human long non-coding RNA gene that regulates transcription and cellular processes. It participates in restraining breast cancer progression by modulating cell viability, proliferation, migration, and invasion via the microRNA-513a-5p/KLF6 axis[1][5], and is involved in mesenchymal stem cell differentiation and bone regeneration by repressing IL-1β through the Wnt/β-catenin pathway[2]. It can serve as a therapeutic target for nucleic acid-based interventions, and its expression may have biomarker potential for cancer prognosis and skeletal regenerative medicine[4][8].

Other names: lnc13728CTC-564N23.3ZBED3 antisense RNA 1 (non-protein coding)

Mechanism of action

For potential ASO therapies: RNA silencing/knockdown of ZBED3-AS1

Biological functions

Gene expression regulation, neoplasticInduction of mesenchymal stem cell differentiationRegulation of osteogenesis and bone regenerationModulator of cell viability, proliferation, migration, and invasion in cancer contexts

Disease associations

Cancer (notably breast cancer)Glioma susceptibilityPotential relevance in bone diseases (bone regeneration)

Safety considerations

None reportedTherapeutic targeting of lncRNAs generally presents challenges of specificity and off-target effectsNo unique issues have been identified for ZBED3-AS1

Biomarkers

Expression level of ZBED3-AS1 in cancer (breast cancer), especially as a marker for restrained progressionmay also function as a marker in bone regeneration studies

Beyond the preview

Go deeper on ZBED3 antisense RNA 1 (ZBED3-AS1).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on ZBED3 antisense RNA 1 (ZBED3-AS1).

Explore the full profile