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Target intelligence / Profile preview
ZBTB20 antisense RNA 1 (ZBTB20-AS1)
- Target
- ZBTB20-AS1
- Molecular classification
- Long non-coding RNA, Non-protein coding RNA
01
Overview
ZBTB20 antisense RNA 1 is a human long non-coding RNA located on chromosome 3 that regulates its sense gene ZBTB20. It mediates cellular processes including apoptosis by inhibiting ZBTB20 expression and activating the GSK-3β/Tau phosphorylation pathway, contributing to neurodegenerative conditions like Alzheimer's disease[1][2][3]. Because it is a non-coding RNA, it does not encode a protein and is not a traditional pharmaceutical target, but its regulatory role makes it of interest in disease mechanism studies.
- Other names
- ZBTB20 antisense RNA 1 (non-protein coding)ZBTB20-AS1LOC101929754 (occasionally listed)
02
Biological functions
Regulation of apoptosisModulation of ZBTB20 gene expressionRegulation of GSK-3β expression and Tau phosphorylation
03
Disease associations
Alzheimer's disease (promotes disease progression via inhibition of ZBTB20, promotion of GSK-3β, and increased Tau phosphorylation)Potential association with Primrose Syndrome (listed in gene-disease databases)
04
Safety considerations
None reported specifically, but as a lncRNA involved in apoptosis and neurodegeneration, off-target effects would be a concern for any future RNA-based therapy
05
Biomarkers
ZBTB20-AS1 expression levels may act as biomarkers for Alzheimer's disease progression or prognosis, given its upregulation in disease models
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