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ZBTB40 intronic transcript 1 (ZBTB40-IT1)
- Target
- ZBTB40-IT1
- Molecular classification
- Long non-coding RNA, Other
01
Overview
ZBTB40 intronic transcript 1 (ZBTB40-IT1) is a long non-coding RNA gene located within or near the ZBTB40 locus, which is associated with bone density and osteoporosis susceptibility. ZBTB40-IT1 acts by suppressing osteoblast differentiation and promoting osteoclast activity, therefore playing a role in bone metabolism. Its expression is regulated by SNPs linked to osteoporosis risk, and it modulates downstream targets including WNT4, RUNX2, and COL1A1. Currently available evidence supports its functional relevance in osteoporosis but does not indicate that it is a therapeutic target for drugs or small molecules[1][4].
- Other names
- ZBTB40-IT1ZBTB40 intronic transcript 1
02
Biological functions
Regulation of osteogenesis (bone formation)Promotion of osteoclastogenesis (bone resorption)Regulation of gene expression (notably WNT4, RUNX2, OSX, ALP, COL1A1, OPG, RANKL)
03
Disease associations
Osteoporosis
04
Biomarkers
Osteoporosis GWAS SNPs (e.g., rs34920465, rs6426749) influence ZBTB40-IT1 expression
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