ZDHHC8B, pseudogene (ZDHHC8BP)

ZDHHC8B, pseudogene (abbreviation ZDHHC8BP, sometimes annotated as FLJ31568), is a nonfunctional copy of the ZDHHC8 gene in the human genome. Pseudogenes have traditionally been classified as non-coding “junk DNA,” but recent research indicates many are transcribed and can act as regulators of gene expression rather than encoding functional proteins. Some pseudogene transcripts can serve as competitive endogenous RNAs (ceRNAs), microRNA decoys, or sources of regulatory small RNAs such as siRNAs. Several human pseudogenes are implicated in diverse biological processes and disease states by modulating the activity of their parent genes or interfering with microRNA networks, although ZDHHC8BP itself is not currently documented as playing a specific, validated regulatory or disease role[1][4]. It is therefore considered neither a receptor, enzyme, transporter, nor a direct therapeutic target. If you require structured annotations for database mapping, “ZDHHC8B, pseudogene” should be listed as a non-target pseudogene, with no associated drugs or mechanisms, and flagged as a molecular non-target (is_target: false; is_incorrect: true due to its pseudogene status).

Other names

FLJ31568ZDHHC8BP

None reported for drugs; general functional pseudogene mechanisms include miRNA “sponging”/decoy activity, antisense regulation, and generation of small interfering RNAs (siRNAs) that may modulate related gene expression