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Target intelligence / Profile preview
Zeta-chain-associated protein kinase 70 (ZAP70)
- Target
- ZAP70
- Molecular classification
- Enzyme, Protein Kinase, Tyrosine Kinase, Syk family kinases
01
Overview
Zeta-chain-associated protein kinase 70 (ZAP70) is a cytoplasmic tyrosine kinase critical for T cell receptor (TCR) signaling. It transduces signals from activated TCR complexes, driving T cell activation, differentiation, proliferation, and cytokine secretion. ZAP70 contains two N-terminal SH2 domains that bind to phosphorylated ITAMs on the TCR ζ chain, and a C-terminal kinase domain. Mutations in ZAP70 can cause severe combined immunodeficiency (SCID), characterized by the absence or dysfunction of CD8+ T cells.
- Other names
- ZAP-70
02
Mechanism of action
Tyrosine kinase inhibition (potential)
03
Biological functions
Signal transductionImmune responseT cell activationT cell differentiationT cell proliferationCytokine secretionActin-mediated membrane rearrangementNK cell activity
04
Disease associations
Severe combined immunodeficiency (SCID)ZAP70-related SCIDImmune dysregulationInfection
05
Safety considerations
Immunosuppression if targeted therapeutically
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