ZFP91 zinc finger protein, atypical E3 ubiquitin ligase (ZFP91)

ZFP91 zinc finger protein, atypical E3 ubiquitin ligase (ZFP91) is a protein coding gene encoding a zinc finger family protein with C2H2-type domains. ZFP91 functions as an atypical E3 ubiquitin ligase, mediating Lys-63-linked ubiquitination of MAP3K14 (NIK), thereby stabilizing and activating NIK, and serves as a regulator of the non-canonical NF-κB (NFKB2) pathway within lymphotoxin-beta receptor signaling[2][3][5][7]. ZFP91 may also participate in transcriptional regulation, cell proliferation, and anti-apoptotic processes. Diseases associated with ZFP91 include acute myeloid leukemia and Duane-radial ray syndrome[3]. ZFP91 is part of a broader zinc finger protein family known to regulate gene expression, modulate immune responses, and contribute to tumorigenesis in various cancers[1][3]. No direct interacting drugs, approved biomarkers, or current clinical inhibitors of ZFP91 are recognized in the provided literature. The gene is considered a potential therapeutic target, particularly in malignancies linked to dysregulated NF-κB signaling.

Other names

ZNF757PZFZFP-91E3 ubiquitin-protein ligase ZFP91RING-type E3 ubiquitin transferase ZFP91Zinc finger protein 757Zinc finger protein 91 homologDrug resistance-associated sequence in melanoma 8Penta zinc finger proteinZinc finger protein homologous to Zfp91 in mouseFKSG11DSM-8

Drugs targeting ZFP91 would likely act via inhibition of its ubiquitin ligase activity, disruption of protein-protein interactions (e.g., with MAP3K14/NIK), or interference with NF-κB non-canonical pathway signaling.