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Target intelligence / Profile preview
Zika virus envelope protein
- Molecular classification
- Glycoprotein, Viral fusion protein
01
Overview
The Zika virus envelope (E) protein is a structural glycoprotein on the surface of the Zika virus. It mediates attachment to host cells and membrane fusion, enabling viral entry. It is a major antigenic determinant and target for neutralizing antibodies, making it a key target for vaccine and therapeutic development. Glycosylation at N154 affects infectivity, immune evasion, and pathogenesis.
02
Mechanism of action
Attachment inhibition; Fusion inhibition; Neutralizing antibody binding
03
Biological functions
Viral entryMembrane fusionImmune evasionHost cell attachment
04
Disease associations
InfectionZika virus diseaseMicrocephaly
05
Safety considerations
Antibody-dependent enhancement (ADE) needs to be considered in therapeutic antibody development
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