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Zika virus envelope protein

Molecular classification: Glycoprotein, Viral fusion protein

Overview

The Zika virus envelope (E) protein is a structural glycoprotein on the surface of the Zika virus. It mediates attachment to host cells and membrane fusion, enabling viral entry. It is a major antigenic determinant and target for neutralizing antibodies, making it a key target for vaccine and therapeutic development. Glycosylation at N154 affects infectivity, immune evasion, and pathogenesis.

Mechanism of action

Attachment inhibition; Fusion inhibition; Neutralizing antibody binding

Biological functions

Viral entryMembrane fusionImmune evasionHost cell attachment

Disease associations

InfectionZika virus diseaseMicrocephaly

Safety considerations

Antibody-dependent enhancement (ADE) needs to be considered in therapeutic antibody development

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