Zika virus premembrane protein (prM)

The Zika virus premembrane protein (prM) is a viral structural protein that serves as a precursor to the mature membrane protein[1][2]. It plays a critical role in viral assembly, maturation, and infection by forming heterodimeric complexes with the envelope protein and protecting the fusion loop during transit through acidic intracellular compartments[1][2]. The prM protein stabilizes immature viral particles and is subsequently cleaved by the host protease furin to generate mature virions capable of cell-to-cell transmission[1][2]. Because prM is essential for multiple stages of the viral life cycle—including particle assembly, stabilization, and maturation—it represents a potential therapeutic target for Zika virus infection, though its fundamental role in viral replication means that inhibition strategies must be carefully designed to avoid resistance or unintended effects[2].

Other names

pre-envelope proteinmembrane protein precursor

Inhibition of prM function could prevent proper viral particle assembly and maturation. Agents could stabilize the prM-E complex to prevent the conformational changes necessary for viral fusion.