Zinc-Dependent Enzyme

Zinc-dependent enzymes are a broad class of metalloenzymes that require zinc ions (Zn²⁺) for their catalytic activity, structural stability, or regulatory functions. Zinc acts as a crucial cofactor in these proteins, participating directly in catalysis or maintaining the enzyme's three-dimensional structure. They are involved in diverse biological processes including DNA repair, gene expression regulation, and cell signaling, and are implicated in diseases such as cancer, neurodegenerative disorders and infections. Examples include Histone deacetylases (HDACs), Cytosine deaminase, Phospholipase C and Macrodomains.

Inhibition of enzymatic activity through zinc chelation or active site binding.