Zinc finger, X-linked, duplicated family member C (ZXDC)

ZXDC is a transcription factor containing two C2H2-type zinc finger domains near its C-terminus, facilitating DNA binding and transcriptional control[1][2]. It must form oligomeric complexes with itself or with the related protein ZXDA to bind the class II trans-activator (CIITA)[2], thereby activating transcription of MHC class I and II genes, which are essential for immune responses[1][2]. ZXDC is activated by sumoylation, a post-translational modification[1]. It interacts with proteins such as GSK3β and p53, influencing processes like cell cycle progression, proliferation, apoptosis, and immune system regulation[1]. Research indicates ZXDC is relevant in cancer biology, immune function, and potentially as a molecular target for autoimmune and malignant disease therapies[1][2]. ZXDC is highly conserved across species, signifying its critical role in cellular processes[1]. If you require more detailed pathway or drug interaction data, further experimental results or pharmaceutical studies would be needed, as direct clinical targeting is not yet established for ZXDC[3][4].

Other names

ZXDCZXDLZXD family zinc finger CZinc finger protein ZXDCZXD-like zinc finger proteinMGC11349FLJ13861SERH2790

No approved drugs; mechanism would likely involve modulating transcription of immune or cell cycle genes