Zinc finger AN1-type containing 6 (ZFAND6)

Zinc finger AN1-type containing 6 (ZFAND6) is a protein-coding gene and a member of the zinc finger protein family containing AN1-type and A20-type domains[1][2][4]. Biochemically, ZFAND6 is involved in the negative regulation of NF-kappaB signaling and apoptosis, largely by modulating ubiquitination states of key signaling proteins such as TRAF2 in the TNF receptor pathway[1][2]. ZFAND6 is located in the cytosol and also participates in regulating peroxisomal protein import and supporting PEX5 stability[1]. Recent studies indicate a broader regulatory role for ZFAND6 in inflammation, the metabolic axis (including the risk for type 2 diabetes by influencing pancreatic beta cell function), and innate antiviral immunity[2][4]. ZFAND6-deficient mice exhibit resistance to certain viral infections but are more susceptible to immune-mediated damage, pointing to a key role in balancing immune responses[4]. No approved drugs directly target ZFAND6, but it represents a potential node for future therapeutic intervention in metabolic, inflammatory, and infectious diseases. Overall, ZFAND6 is classified as an ubiquitin-signaling modulator within the zinc finger protein superfamily, and while not a classic "receptor," it is an emerging therapeutic target due to its roles in disease-associated pathways[1][2][4].

Other names

AWP1ZA20D3HT032ZFAND5BAssociated with PRK1 proteinZinc finger A20 domain-containing protein 3Protein associated with PRK1Zinc finger, AN1-type domain 6Zinc finger, A20 domain containing 3

Not established for approved drugs—potential mechanisms based on protein regulation could involve modulation of ubiquitination or NF-kappaB signaling