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Zinc finger and BTB domain containing 21 (ZBTB21)
- Target
- ZBTB21
- Molecular classification
- Transcription factor, Zinc finger protein, BTB/POZ domain protein
01
Overview
Zinc finger and BTB domain containing 21 (ZBTB21) is a protein-coding gene that encodes a member of the ZBTB family of transcription factors, characterized by the presence of C2H2-type zinc fingers and a BTB/POZ domain. The protein acts as a transcriptional repressor by binding to DNA and recruiting corepressors, which mediate gene silencing through chromatin remodeling and methyl-CpG binding. ZBTB21 is localized in the cytosol and nucleoplasm. Mutations in ZBTB21 are linked to neurodevelopmental disorders such as Coffin-Siris Syndrome 1 and Intellectual Developmental Disorder, Autosomal Dominant 7. Its molecular function is inferred mainly from homology with other ZBTB proteins which control cell differentiation, proliferation, and apoptosis via regulation of gene expression[3].
- Other names
- ZBTB21ZNF295
02
Biological functions
Negative regulation of transcription by RNA polymerase IIDNA-binding transcriptional repressor activityMethyl-CpG bindingProtein-protein interaction via BTB/POZ domain
03
Disease associations
Intellectual developmental disorder (Autosomal Dominant 7)Coffin-Siris Syndrome 1Other neurodevelopmental disorders
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