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Target intelligence / Profile preview
Zinc finger and BTB domain-containing protein 2 (ZBTB2)
- Target
- ZBTB2
- Molecular classification
- Transcription factor, Zinc finger protein, BTB/POZ domain-containing protein
01
Overview
Zinc finger and BTB domain-containing protein 2 (ZBTB2) is a member of the BTB/POZ family of transcription factors that acts primarily as a transcriptional repressor. It contains zinc finger motifs mediating DNA binding and a BTB/POZ domain that facilitates protein-protein interactions. ZBTB2 represses genes within the ARF-HDM2-p53-p21 axis critical for cell cycle control, acting as a master regulator that can inhibit the cell cycle arrest function of p53 by direct DNA binding and interaction with transcription factors such as Sp1. ZBTB2 associates with chromatin-modifying complexes (including NuRD and HiRA) and regulates chromatin structure during stem cell differentiation and development. Dysregulation or abnormal expression of ZBTB2 is implicated in cancer biology as a potential proto-oncogene and is associated with certain inherited retinal degenerative diseases.
- Other names
- Zinc finger and BTB domain containing 2KIAA1483ZNF437bA351K16.2
02
Biological functions
Negative regulation of transcriptionDNA-bindingRepression of p53 pathway genes (ARF, p53, p21)Chromatin remodelingRegulation of embryonic stem cell differentiationCell proliferation
03
Disease associations
Cancer (proto-oncogenic role, dysregulation of the p53 pathway)Retinal diseases (Retinitis pigmentosa 10, Leber congenital amaurosis 11)
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