Zinc finger and BTB domain-containing protein 33 (ZBTB33)

Zinc finger and BTB domain-containing protein 33 (ZBTB33, also known as Kaiso) is a transcription factor belonging to the POZ/BTB zinc finger protein family, with bimodal DNA-binding specificity for both methylated CpG sites and specific non-methylated DNA motifs. It contains an N-terminal POZ/BTB domain and three C-terminal Krüppel-like zinc finger motifs, mediating interaction with corepressor complexes and recruitment of histone deacetylases for chromatin remodeling[1][4]. ZBTB33 can repress or activate transcription of target genes, including those in the Wnt signaling pathway, and is a critical modulator of p53-mediated responses to genotoxic stress such as cell cycle arrest and apoptosis[1][2]. Its activity is regulated by interactions with catenin family proteins and nuclear transport machinery. ZBTB33/Kaiso is implicated in cancer progression, especially breast cancer, where its subcellular localization holds biomarker significance[3].

Other names

KaisoTranscriptional regulator KaisoZNF348ZNF-kaisoKAISOkaiso transcription factorWUGSC:H_DJ525N14.1

Facilitation of p53 acetylation (in presence of DNA-damaging agents)[2]; Recruiter of corepressor complexes to methylated DNA[1]; Regulator of p53-mediated cell cycle arrest and apoptosis in response to genotoxic stress[2]