Zinc finger and BTB domain-containing protein 49 (ZBTB49)

Zinc finger and BTB domain-containing protein 49 (ZBTB49) is a sequence-specific DNA-binding transcription factor that contains a BTB/POZ domain and multiple C2H2 zinc finger motifs[1][5][13]. It can inhibit cell proliferation by activating transcription of CDKN1A/p21 and RB1, two key regulators of the cell cycle, and is involved in cell cycle and transcriptional control[1][9][5]. ZBTB49 acts as a transcription activator or coactivator, potentially interacting with proteins such as EP300 and ZBTB17/Miz-1[1]. Expression patterns suggest a possible role in relation to cancer biology, but it is not currently considered a validated or widely utilized therapeutic target or biomarker[8][1][5]. Key supporting evidence: - Aliases and identifiers: Multiple synonyms and IDs are attributed to this gene, including ZNF509 and FLJ38559[1][13]. - Classification: This protein has canonical C2H2 zinc finger motifs and a BTB (Broad complex, Tramtrack, and Bric à brac) domain typical of a family of transcription factors[1][12][7][5]. - Functions: Experimental data support its role as a negative regulator of cell proliferation via transcriptional activation of cell cycle inhibitors and suggest broader involvement in transcriptional regulation[1][9][5]. - Disease role: Members of the BTB-ZF family play roles in T cell development and hematopoiesis, as well as tumorigenesis, but specific roles for ZBTB49 in disease remain to be clearly defined[4][7][8]. - Therapeutic targeting: No drugs, mechanism of action data, or established safety concerns are currently reported for this protein[1][5][8].

Other names

ZNF509FLJ38559Zinc finger protein 509zinc finger and BTB domain containing 49zinc finger protein 509