Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Zinc finger and BTB domain-containing protein 7A (ZBTB7A)
- Target
- ZBTB7A
- Molecular classification
- Transcription factor
01
Overview
Zinc finger and BTB domain-containing protein 7A (ZBTB7A) is a transcription factor that acts primarily as a transcriptional repressor. It binds to specific DNA elements via its zinc-finger domains and represses gene expression through chromatin modification or direct recruitment of corepressors. Aberrant expression or mutation of ZBTB7A is implicated in various diseases, including cancer and developmental disorders. It can act as either an oncogene or a tumor suppressor depending on the cellular context.
- Other names
- Factor binding IST protein 1FBI-1Factor that binds to inducer of short transcripts protein 1HIV-1 1st-binding protein 1Leukemia/lymphoma-related factorPOZ and Krueppel erythroid myeloid ontogenic factorPOK erythroid myeloid ontogenic factorPokemonTIP21TTF-I-interacting peptide 21Zinc finger protein 857A
02
Mechanism of action
Transcriptional repression via DNA binding and recruitment of corepressors.
03
Biological functions
Cell proliferationCell differentiationCell developmentHematopoiesisAdipogenesisChondrogenesisCellular metabolism regulationAlternative splicingDNA repairOsteoclast developmentUnfolded protein responseTranscriptional repressionChromatin modification
04
Disease associations
CancerMacrocephaly with neurodevelopmental delayLymphoid hyperplasiaPersistent fetal hemoglobinSleep apnea syndromes
05
Safety considerations
Context-dependent oncogene or tumor suppressor activity.Repression of p14ARF/p19ARF leading to p53 pathway inhibition.
Beyond the preview
Go deeper on Zinc finger and BTB domain-containing protein 7A (ZBTB7A).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Zinc finger and BTB domain-containing protein 7A (ZBTB7A).